AUTOlNJECTOR SYRlNGE lNSTRUCTlONS
Benepali^™ Syringe

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HOW TO USE BENEPALl^™

THE BENEPALI^™ SYRlNGE

Available as a 25 mg or 50 mg pre-filled syringe¹

Needle cover

Plunger

Latex Free³

Reassurance for patients with
latex allergy or their family

Ergonomic
Finger Grip²

Stainless steel³

27 gauge needle

Needle cover

Latex Free

Reassurance for patients with
latex allergy or their family

Ergonomic
Finger Grip

Stainless steel⁵

27 gauge needle

Plunger

Patient guide video on how to use the Benepali^™
(etanercept) syringe

^a Syringe must be protected from light and discarded if not used within the 31-day period, even if it is returned to the refrigerator.

REFERENCES

lNJECTlON SlTE CARE

The Benepali^TM pre-filled syringe is for a subcutaneous injection. It should be injected into the thigh, abdomen, or back of the upper arm

Rotate the site for each injection.

If you are injecting into the abdomen, choose a site that is at least 5 cm away from the belly button.

Do not inject into areas that are red, hard, bruised, or tender.
Do not inject into scars or stretch marks.
If you have psoriasis, do not inject into any raised, thick, red, or scaly skin patches, or lesions.

BEFORE YOU START

1. Inspect the pre-filled syringe:

Check the expiry date on the pre-filled syringe label.

• Do not use the pre-filled syringe past the expiration date.

• Do not use the pre-filled syringe if it has been dropped onto a hard surface. Components inside the pre-filled syringe may be broken.

• Do not use the pre-filled syringe if the needle cover is missing or not securely attached.

2. Inspect the solution:

Look at the medicine in the pre-filled syringe.

The medicine should be clear to slightly opalescent, colourless or pale yellow, and may contain small white or almost transparent particles of protein.

• Do not use the solution if it is discoloured, cloudy, or if particles other than those described above are present.

3. Allow the medicine to reach room temperature:

Remove one pre-filled syringe from the refrigerator and leave at room temperature for at least 30 minutes before injecting.

This is important to make the medicine easier and more comfortable to inject.

• Do not remove the needle cover until you are ready to inject.

• Do not use heat sources, such as a microwave or hot water, to warm Benepali^™.

SYRlNGE lNJECTlON lNSTRUCTlONS

DOWNLOAD

Before you inject, ask your doctor or nurse to show you how to use your pre-filled syringe.

Quick Use Guide

This quick use guide is a shortened version of the patient information leaflet. These instructions are supplied as a guide only.

Please read the full patient information leaflet before you use your syringe for the first time.¹ This guide is available for HCPs to download for their patients.

Do not try to give yourself the injection unless your doctor or nurse has shown you how to give the injection.

REMOVE THE PRE-FILLED SYRINGE FROM THE REFRIGERATOR AT LEAST 30 MINS PRIOR TO INJECTION TO MAKE THE MEDICINE EASIER AND MORE COMFORTABLE TO INJECT.

CHOOSE AN INJECTION SITE

THE BENEPALI^TM PRE-FILLED SYRINGE IS FOR A SUBCUTANEOUS INJECTION. IT SHOULD BE INJECTED INTO THE THIGH, ABDOMEN, OR BACK OF THE UPPER ARM.
ROTATE THE SITE FOR EACH INJECTION.

If you are injecting into the abdomen, choose a site that is at least 5 cm away from the belly button.

Do not inject into areas that are red, hard, bruised, or tender.

Do not inject into scars or stretch marks.

If you have psoriasis, do not inject into any raised, thick, red, or scaly skin patches, or lesions.

1 WASH YOUR HANDS WITH SOAP AND WATER.

2 WIPE THE SKIN AT THE INJECTION SITE WITH AN ALCOHOL SWAB.

Do not touch this area again before giving the injection.

3 PULL THE NEEDLE COVER STRAIGHT OFF AND DISPOSE OF IT IN THE BIN OR SHARPS CONTAINER.

Do not twist or bend the needle cap while removing it, as this may damage the needle.
Do not touch the plunger rod while removing the needle cover.
Never recap the needle.

4 GENTLY PINCH A FOLD OF SKIN AT THE CLEANED INJECTION SITE. HOLD THE PREFILLED SYRINGE AT 45 DEGREES TO THE SKIN. WITH A QUICK, DART-LIKE MOTION, INSERT THE NEEDLE FULLY INTO THE SKIN.

You can let go of the skin that you are pinching after the needle is completely inserted.

5 SLOWLY PUSH DOWN THE PLUNGER TO INJECT ALL OF THE BENEPALI™ SOLUTION.

6 WHEN THE SYRINGE IS EMPTY, REMOVE THE NEEDLE FROM THE SKIN AT THE SAME ANGLE AS INSERTED.

Never recap the needle. Recapping could lead to a needle stick injury.

DISPOSAL

DISPOSE OF THE ENTIRE SYRINGE IN AN APPROVED SHARPS CONTAINER

Check with your healthcare provider for instructions on how to properly dispose a filled sharps container.

Sharps disposal containers may be purchased at your local pharmacy.

Do not throw the sharps container in household bin.

Do not recycle.

Do not reuse Benepali pre-filled syringe.

Always keep the container out of the sight and reach of children.

INJECTION SITE CARE

If there is bleeding at the injection site, press a gauze pad over the injection site.

Do not rub the injection site.

If needed, cover the injection site with a plaster.